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GHRP6
GHRP6
GHRP6 is a true HGH
GHRP6 is a peptide and is among the growth
factor hormones. It is made up of 28 amino
acids and is a true growth hormone (HGH)
secretagogue, which stimulates the body’s
secretion of growth hormone (GH). Basically,
GHRP6 tells the body to produce more HGH
and IGF-1, which in turn promotes a huge
range of benefits.
Benefits:
• Increase of muscle mass
• Increase in strength and stamina
• Decrease of body fat
• Helps bone tissue growth
• Makes liver secrete IGF-1, which helps
in burning body fat and increasing muscle
• Anti-aging peptide
• Enhances immune response
• Strengthens joints, connective tissue,
and body mass
• Quick effect on Ghrelin, which is tied
to weight gain and insulin resistance
GHRP 6: Growth Hormone Releasing Peptide
Purity: 98% (HPLC on request)
Molecular Formula: C46H56N12O6 Molecular Weight: 873.01 CAS No.: 873.01
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Description
GHRP 6 is not an active fragment of growth hormone releasing hormone (GHRH). It is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids that were developed for
their growth hormone releasing activity and are called growth hormone secretagogues. GHRP 6 is
a true hGH secretagogue. Which means it stimulates the body’s own secretion of hGH as explained
in the study below. Human Growth hormone has been shown in studies to promote lean body mass
and reduce adiposity (fat). It is now known that these growth hormone releasing peptides are distinct
from GHRH and do not act at the GHRH receptor, but instead act at the growth hormone secretagogue receptor, now renamed as the ghrelin receptor. It is for this reason (gherlin like properties)
patients being treated with GHRP 6 experience appetite stimulation. In therapy GHRP 6 is used to
stimulate growth hormone production whilst increasing body mass. Patients deficient in growth hormone and underweight would be ideal candidates for GHRP 6.
Protocol
Content and Potency: 10mL (2 x 5mL) at 2000mcg/ml ready-to-inject subcutaneous (10weeks).
Suggested dosage: 0.2ml daily 5 days out of 7 or 0.1ml twice-daily 5 days out of 7 between 6 - 8pm.
Transdermal Option: 200mcg/mL x 100mL – Apply 1mL twice daily 5 days out of 7
Clinical Research
Growth hormone releasing peptide (GHRP 6) stimulates phosphatidylinositol (PI) turnover in human
pituitary somatotroph cells.
Lei T, Buchfelder M, Fahlbusch R, Adams EF.
Source: Department of Neurosurgery, University of Erlangen-Nürnberg, Germany.
Abstract: Growth hormone releasing peptide (GHRP 6) is a synthetic hexapeptide which specifically
stimulates secretion of growth hormone (GH) by pituitary somatotrophs. The precise intracellular
mechanism by which this is achieved has not been deciphered although it is known to involve protein kinase C (PKC) and Ca2+ but to be cAMP-independent. We have used cell cultures of human
pituitary somatotrophinomas to demonstrate powerful effects of GHRP 6 on membrane phosphatidylinositol (PI) turnover, a second messenger system which leads to activation of PKC and mobilisation of intracellular Ca2+ reserves. Incubation of somatotrophinoma cells with GHRP 6 led to a
dose-dependent stimulation of rate of PI turnover. GH secretion was increased in parallel. Effects
were discernable after only 15 minutes incubation and rose to a maximum at 2 hours. PI turnover
was stimulated by GHRP 6 in 8 of 8 tumours examined, effects ranging from 2.1 - 7.9 fold increases.
Stimulation of GH secretion by GHRP 6 was independent of presence of gsp oncogenes, emphasising the cAMP-independent nature of its effects. These results provide evidence that the GH-stimulatory effects of GHRP 6 are achieved through activation of the PI second messenger system and thus
support earlier findings that PKC and Ca2+ play central roles in mediating the effects of GHRP 6.
GHRP6 is a peptide and is among the growth
factor hormones. It is made up of 28 amino
acids and is a true growth hormone (HGH)
secretagogue, which stimulates the body’s
secretion of growth hormone (GH). Basically,
GHRP6 tells the body to produce more HGH
and IGF-1, which in turn promotes a huge
range of benefits.
Benefits:
• Increase of muscle mass
• Increase in strength and stamina
• Decrease of body fat
• Helps bone tissue growth
• Makes liver secrete IGF-1, which helps
in burning body fat and increasing muscle
• Anti-aging peptide
• Enhances immune response
• Strengthens joints, connective tissue,
and body mass
• Quick effect on Ghrelin, which is tied
to weight gain and insulin resistance
GHRP 6: Growth Hormone Releasing Peptide
Purity: 98% (HPLC on request)
Molecular Formula: C46H56N12O6 Molecular Weight: 873.01 CAS No.: 873.01
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Description
GHRP 6 is not an active fragment of growth hormone releasing hormone (GHRH). It is one of several synthetic met-enkephalin analogs that include unnatural D-amino acids that were developed for
their growth hormone releasing activity and are called growth hormone secretagogues. GHRP 6 is
a true hGH secretagogue. Which means it stimulates the body’s own secretion of hGH as explained
in the study below. Human Growth hormone has been shown in studies to promote lean body mass
and reduce adiposity (fat). It is now known that these growth hormone releasing peptides are distinct
from GHRH and do not act at the GHRH receptor, but instead act at the growth hormone secretagogue receptor, now renamed as the ghrelin receptor. It is for this reason (gherlin like properties)
patients being treated with GHRP 6 experience appetite stimulation. In therapy GHRP 6 is used to
stimulate growth hormone production whilst increasing body mass. Patients deficient in growth hormone and underweight would be ideal candidates for GHRP 6.
Protocol
Content and Potency: 10mL (2 x 5mL) at 2000mcg/ml ready-to-inject subcutaneous (10weeks).
Suggested dosage: 0.2ml daily 5 days out of 7 or 0.1ml twice-daily 5 days out of 7 between 6 - 8pm.
Transdermal Option: 200mcg/mL x 100mL – Apply 1mL twice daily 5 days out of 7
Clinical Research
Growth hormone releasing peptide (GHRP 6) stimulates phosphatidylinositol (PI) turnover in human
pituitary somatotroph cells.
Lei T, Buchfelder M, Fahlbusch R, Adams EF.
Source: Department of Neurosurgery, University of Erlangen-Nürnberg, Germany.
Abstract: Growth hormone releasing peptide (GHRP 6) is a synthetic hexapeptide which specifically
stimulates secretion of growth hormone (GH) by pituitary somatotrophs. The precise intracellular
mechanism by which this is achieved has not been deciphered although it is known to involve protein kinase C (PKC) and Ca2+ but to be cAMP-independent. We have used cell cultures of human
pituitary somatotrophinomas to demonstrate powerful effects of GHRP 6 on membrane phosphatidylinositol (PI) turnover, a second messenger system which leads to activation of PKC and mobilisation of intracellular Ca2+ reserves. Incubation of somatotrophinoma cells with GHRP 6 led to a
dose-dependent stimulation of rate of PI turnover. GH secretion was increased in parallel. Effects
were discernable after only 15 minutes incubation and rose to a maximum at 2 hours. PI turnover
was stimulated by GHRP 6 in 8 of 8 tumours examined, effects ranging from 2.1 - 7.9 fold increases.
Stimulation of GH secretion by GHRP 6 was independent of presence of gsp oncogenes, emphasising the cAMP-independent nature of its effects. These results provide evidence that the GH-stimulatory effects of GHRP 6 are achieved through activation of the PI second messenger system and thus
support earlier findings that PKC and Ca2+ play central roles in mediating the effects of GHRP 6.
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