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GHRP2
GHRP2
Energy and endurance increasing peptide
GHRP2 substantially stimulates the pituitary gland’s increased natural production of
the body’s own endogenous human growth hormone (HGH). GHRP2 has shown on
its own to robustly increase IGF-1 levels,
and even greater results occurred when
used with Growth Hormone Releasing
Hormone (GHRH) to which also stimulates
the pituitary gland to produce increased
natural secretion of human growth hormone.
This also boosts the hypothalamus function as well.
Benefits:
• Increases energy and vitality
• Increases endurance
• Accelerates healing from wounds
• Strengthens the heart
• Reduces fat through lipolysis
• Enhances the immune system
• Stimulation of hypothalamus
• Increases IGF-1 production, by as much
as 50% in first week
• Increases calcium retention, strengthens
and increases the mineralization of bone,
bone density
• Increases protein synthesis
GHRP 2: Growth Hormone Releasing Peptide
Purity: 98% (HPLC on request)
Molecular Formula: C42H50N8O5 Molecular Weight: 749.9 CAS No.: 87616-84-0
Sequence: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Description
Growth Hormone Releasing Peptide-2 (GHRP 2) is a peptide made up of just six amino acids, which
stimulates secretion of endogenous GH. Research shows GHRP 2 can stimulate the pituitary to
increase secretion of GH by 7-15 times, stimulating ghrelin receptors to promote appetite. GHRP 2
acts as a synthetic ghrelin analogue that stimulates the release of an endogeneous growth hormone
within the somatotropes of the anterior pituitary. Specifically, GHRP 2 will increase the number of
somatotropes in a GH pulse by limiting the amount of somatostatin present while standard GHRH
increases the amplitude at which the pituitary cells pulse.
The main effects of GHRP 2 are GH secretion, appetite enhancement, fat mass decrease and muscle mass increase, lowering of cholesterol level, skin and bone strengthening, protection of the liver
and anti-inflammatory action. GHRP 2 possesses many repair properties that can be attributed to its
immune boosting function. GHRP 2 has been shown to increase prolactin, aldosterone and cortisol
levels and in some cases may not be the peptide of choice.
Protocol
Content and Potency: 1 x 5mL at 2000mcg/ml ready-to-inject subcutaneous.
Suggested dosage: 0.10ml daily 5 days out of 7 between 6 - 8pm (10 weeks supply).
Transdermal Option: 200mcg/mL x 50mL – Apply 1mL daily 5 days out of 7. (10 weeks supply).
Clinical Research
Growth Hormone Releasing Peptide -2 (GHRP 2), like ghrelin, increases food intake in healthy men.
Blandine Laferrère, Cynthia Abraham, Colleen D. Russell, and Cyril Y. Bowers
Source: The publisher’s final edited version of this article is available free at J Clin Endocrinol Metab
Abstract: GHRP 2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds
to the growth hormone (GH) secretagogue receptor. Ghrelin has been shown to have two major
effects, stimulating both GH secretion and appetite/meal initiation. GHRP 2 has been extensively
studied for its utility as a growth hormone secretagogue (GHS). Animal studies have shown its effect
on food intake. We subcutaneously infused 7 lean, healthy males with GHRP 2 (1μg/kg/h) or saline
for 270 minutes and then measured their intake of an ad libitum, buffet-style meal. Similar to what
has been reported for ghrelin administration, our subjects ate 35.9±10.9 % more when infused with
GHRP 2 vs. saline, with every subject increasing their intake even when calculated per kg body
weight (136.0±13.0 kJ/kg vs 101.3±10.5 kJ/kg, p=0.008). The macronutrient composition of consumed food was not different between conditions. As expected, serum GH levels rose significantly
during GHRP 2 infusion (AUC 5550±1090 μg/L/240 min vs. 412±161 μg/L/240 min, p=0.003). This
data is the first to demonstrate that GHRP 2, like ghrelin, increases food intake, suggesting that
GHRP 2 is a valuable tool for investigating ghrelin effects on eating behaviour in humans.
GHRP2 substantially stimulates the pituitary gland’s increased natural production of
the body’s own endogenous human growth hormone (HGH). GHRP2 has shown on
its own to robustly increase IGF-1 levels,
and even greater results occurred when
used with Growth Hormone Releasing
Hormone (GHRH) to which also stimulates
the pituitary gland to produce increased
natural secretion of human growth hormone.
This also boosts the hypothalamus function as well.
Benefits:
• Increases energy and vitality
• Increases endurance
• Accelerates healing from wounds
• Strengthens the heart
• Reduces fat through lipolysis
• Enhances the immune system
• Stimulation of hypothalamus
• Increases IGF-1 production, by as much
as 50% in first week
• Increases calcium retention, strengthens
and increases the mineralization of bone,
bone density
• Increases protein synthesis
GHRP 2: Growth Hormone Releasing Peptide
Purity: 98% (HPLC on request)
Molecular Formula: C42H50N8O5 Molecular Weight: 749.9 CAS No.: 87616-84-0
Sequence: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
Description
Growth Hormone Releasing Peptide-2 (GHRP 2) is a peptide made up of just six amino acids, which
stimulates secretion of endogenous GH. Research shows GHRP 2 can stimulate the pituitary to
increase secretion of GH by 7-15 times, stimulating ghrelin receptors to promote appetite. GHRP 2
acts as a synthetic ghrelin analogue that stimulates the release of an endogeneous growth hormone
within the somatotropes of the anterior pituitary. Specifically, GHRP 2 will increase the number of
somatotropes in a GH pulse by limiting the amount of somatostatin present while standard GHRH
increases the amplitude at which the pituitary cells pulse.
The main effects of GHRP 2 are GH secretion, appetite enhancement, fat mass decrease and muscle mass increase, lowering of cholesterol level, skin and bone strengthening, protection of the liver
and anti-inflammatory action. GHRP 2 possesses many repair properties that can be attributed to its
immune boosting function. GHRP 2 has been shown to increase prolactin, aldosterone and cortisol
levels and in some cases may not be the peptide of choice.
Protocol
Content and Potency: 1 x 5mL at 2000mcg/ml ready-to-inject subcutaneous.
Suggested dosage: 0.10ml daily 5 days out of 7 between 6 - 8pm (10 weeks supply).
Transdermal Option: 200mcg/mL x 50mL – Apply 1mL daily 5 days out of 7. (10 weeks supply).
Clinical Research
Growth Hormone Releasing Peptide -2 (GHRP 2), like ghrelin, increases food intake in healthy men.
Blandine Laferrère, Cynthia Abraham, Colleen D. Russell, and Cyril Y. Bowers
Source: The publisher’s final edited version of this article is available free at J Clin Endocrinol Metab
Abstract: GHRP 2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds
to the growth hormone (GH) secretagogue receptor. Ghrelin has been shown to have two major
effects, stimulating both GH secretion and appetite/meal initiation. GHRP 2 has been extensively
studied for its utility as a growth hormone secretagogue (GHS). Animal studies have shown its effect
on food intake. We subcutaneously infused 7 lean, healthy males with GHRP 2 (1μg/kg/h) or saline
for 270 minutes and then measured their intake of an ad libitum, buffet-style meal. Similar to what
has been reported for ghrelin administration, our subjects ate 35.9±10.9 % more when infused with
GHRP 2 vs. saline, with every subject increasing their intake even when calculated per kg body
weight (136.0±13.0 kJ/kg vs 101.3±10.5 kJ/kg, p=0.008). The macronutrient composition of consumed food was not different between conditions. As expected, serum GH levels rose significantly
during GHRP 2 infusion (AUC 5550±1090 μg/L/240 min vs. 412±161 μg/L/240 min, p=0.003). This
data is the first to demonstrate that GHRP 2, like ghrelin, increases food intake, suggesting that
GHRP 2 is a valuable tool for investigating ghrelin effects on eating behaviour in humans.
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