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PENTOSAN PLATINUM
PENTOSAN PLATINUM
Scientifically Proven Results
Pentosan Platinum is a sterile solution formulated as an aid in the treatment of noninfectious inflammatory joint disease in horses. It is indicated as an aid in the treatment of
non-infectious, inflammatory joint disease in the horse. Clinical applications include the
following conditions: osteoarthritis, osteochondritis dissecans (OCD), traumatic joint and
periarticular inflammation. If used in performance animals, the regulations of the relevant
authorities regarding medication should be observed. It is used to treat pain/discomfort
from a certain bladder disorder (interstitial cystitis). It may work by forming a layer on the
bladder wall and protecting it from harmful/irritating substances in the urine.
Benefits:
Reduces pain, swelling, stiffness in joints and
inflammation for a large variety of injuries and
conditions.
• Long acting pain reliever
• Fast recovery from hard exercise from training or
racing
• Anti-inflammatory activity
• Inhibition of neutrophil migration into the joint.
• Stimulation of hyaluronic acid synthesis by synovial
fibroblasts, resulting in increased volume and
viscosity of synovial fluid.
• Stimulation of proteoglycan synthesis by
chondrocytes.
• Fibrinolytic activity, resulting in improved circulation to
subchondral bone and periarticular structures.
WHAT IS PENTOSAN PLATINUM?
Pentosan polysulfate sodium (PPS) is a semi-synthetic polysaccharide with a linear xylan (pentosan)
backbone. Xylan is a hemicellulose derived from plant origin by extraction from the cell walls of hardwoods.
PPS possesses anti-inflammatory, anti-arthritic and chondroprotective activities.
HOW DOES IT WORK?
Pentosan Platinum actively reverses the effects of osteoarthritis in the joints via a series of actions including:
1. Stimulating Chondrocyte Metabolism: Results in increased production of proteoglycans and healthy
cartilage matrix. PPS stimulates synovial fibroblasts and produces an increased amount of high
molecular weight hyaluronic acid which results in an increased production of normally viscous joint
fluid. Improving the fluid volume and consistency results in more effective joint lubrication and also
stabilisation, which limits further cartilage damage.
2. Anti-inflammatory Activity: PPS has an inhibitory action on all mediators of the arachidonic acid
cascade. PPS also inhibits the lysosomal catabolic enzymes histamine, hyaluronidase, cathepsin B,
and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the
degradation of cartilage matrix components, preserving the cartilage and thus preventing the release of
the highly inflammatory mediators, which relieves pain and inflammation.
(c) Fibrinolysis and Lipolysis: PPS is strongly fibrinolytic, stimulating the release of plasminogen
activator and promotes the dissolution of thrombi and fibrin deposits in synovial tissues and
subchondral blood vessels. PPS also mobilizes lipids and cholesterol in synovial and subchondral
blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals.
These effects combine to increase the pre-fusion to the joint, which stimulates cartilage healing and
repair
WHY USE?
Pentosan Platinum works like an anticoagulant (blood thinner) that prevents the formation of blood clots.
However, it is used to treat bladder pain and discomfort caused by cystitis (bladder inflammation or
irritation).
SIZE
Available in 50ml
ADMINISTRATION AND DOSAGE
Intra-articular - 1mL by aseptic intra-articular injection. Injections may be repeated once weekly for 3 to 4
injections. More than one joint may be treated at a time. The horse should be rested for 2 weeks after the
final injection, followed by a further 2 weeks of graded walking exercise before returning to work. I
Intramuscular - 3mg/kg bodyweight (6mL/500kg horse) by intramuscular injection on four occasions with an
interval of 5-7 days between injections.
INGREDIENTS
Active constituent Pentosan Polysulfate Sodium 250mg/ml.
STORAGE
Should be stored in refrigeration, do not freeze and keep out of sunlight. Once opened, Pentosan Platinum
must be used within 28 days.
Pentosan Platinum is a sterile solution formulated as an aid in the treatment of noninfectious inflammatory joint disease in horses. It is indicated as an aid in the treatment of
non-infectious, inflammatory joint disease in the horse. Clinical applications include the
following conditions: osteoarthritis, osteochondritis dissecans (OCD), traumatic joint and
periarticular inflammation. If used in performance animals, the regulations of the relevant
authorities regarding medication should be observed. It is used to treat pain/discomfort
from a certain bladder disorder (interstitial cystitis). It may work by forming a layer on the
bladder wall and protecting it from harmful/irritating substances in the urine.
Benefits:
Reduces pain, swelling, stiffness in joints and
inflammation for a large variety of injuries and
conditions.
• Long acting pain reliever
• Fast recovery from hard exercise from training or
racing
• Anti-inflammatory activity
• Inhibition of neutrophil migration into the joint.
• Stimulation of hyaluronic acid synthesis by synovial
fibroblasts, resulting in increased volume and
viscosity of synovial fluid.
• Stimulation of proteoglycan synthesis by
chondrocytes.
• Fibrinolytic activity, resulting in improved circulation to
subchondral bone and periarticular structures.
WHAT IS PENTOSAN PLATINUM?
Pentosan polysulfate sodium (PPS) is a semi-synthetic polysaccharide with a linear xylan (pentosan)
backbone. Xylan is a hemicellulose derived from plant origin by extraction from the cell walls of hardwoods.
PPS possesses anti-inflammatory, anti-arthritic and chondroprotective activities.
HOW DOES IT WORK?
Pentosan Platinum actively reverses the effects of osteoarthritis in the joints via a series of actions including:
1. Stimulating Chondrocyte Metabolism: Results in increased production of proteoglycans and healthy
cartilage matrix. PPS stimulates synovial fibroblasts and produces an increased amount of high
molecular weight hyaluronic acid which results in an increased production of normally viscous joint
fluid. Improving the fluid volume and consistency results in more effective joint lubrication and also
stabilisation, which limits further cartilage damage.
2. Anti-inflammatory Activity: PPS has an inhibitory action on all mediators of the arachidonic acid
cascade. PPS also inhibits the lysosomal catabolic enzymes histamine, hyaluronidase, cathepsin B,
and polymorphonuclear elastase. PPS exerts a specific inhibitory effect on mediators implicated in the
degradation of cartilage matrix components, preserving the cartilage and thus preventing the release of
the highly inflammatory mediators, which relieves pain and inflammation.
(c) Fibrinolysis and Lipolysis: PPS is strongly fibrinolytic, stimulating the release of plasminogen
activator and promotes the dissolution of thrombi and fibrin deposits in synovial tissues and
subchondral blood vessels. PPS also mobilizes lipids and cholesterol in synovial and subchondral
blood vessels, which have been implicated in the pathogenesis of osteoarthritis in older animals.
These effects combine to increase the pre-fusion to the joint, which stimulates cartilage healing and
repair
WHY USE?
Pentosan Platinum works like an anticoagulant (blood thinner) that prevents the formation of blood clots.
However, it is used to treat bladder pain and discomfort caused by cystitis (bladder inflammation or
irritation).
SIZE
Available in 50ml
ADMINISTRATION AND DOSAGE
Intra-articular - 1mL by aseptic intra-articular injection. Injections may be repeated once weekly for 3 to 4
injections. More than one joint may be treated at a time. The horse should be rested for 2 weeks after the
final injection, followed by a further 2 weeks of graded walking exercise before returning to work. I
Intramuscular - 3mg/kg bodyweight (6mL/500kg horse) by intramuscular injection on four occasions with an
interval of 5-7 days between injections.
INGREDIENTS
Active constituent Pentosan Polysulfate Sodium 250mg/ml.
STORAGE
Should be stored in refrigeration, do not freeze and keep out of sunlight. Once opened, Pentosan Platinum
must be used within 28 days.
- Regular price
- 0.000 KWD
- Unit price
- per
Tax included.
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